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posted by  Myan on 7/24/2008 9:48:31 AM  |  status: Live  

Renal system

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Please assist with the following
 
1.  What effects would increased blood pressure have on nephron function?
 
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posted by EvilMonkey on 7/24/2008 12:22:38 PM  |  status: Live
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As renal capillary and arterial pressure increase, filtration and reabsorption rates decrease; both in the absolute and proximal fractional rates.

Also, I found in the New England Journal of Medicine, a study suggested that "Patients with hypertension had significantly fewer glomeruli per kidney than matched normotensive controls "

http://content.nejm.org/cgi/content/abstract/348/2/101
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posted by licy on 7/24/2008 1:56:00 PM  |  status: Live
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High blood pressure actually destroys nephrons which are tiny microscopic filtering cells that make the kidney function. By gradually destroying one nephron after another, the kidney’s ability to cleanse the blood becomes progressively compromised. Renal failure occurs when this purification function becomes so impaired that toxin levels build up in the body. With early kidney failure there may be no symptoms.

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posted by Med-Leddy on 7/25/2008 1:25:11 AM  |  status: Live
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n. By gradually destroying one nephron after another, the kidney’s ability to cleanse the blood becomes progressively compromised. We use the term kidney (or renal) failure when this purification function becomes so impaired that toxin levels build up in the body. With early kidney failure there may be no symptoms. As the disease progresses, a person tends to develop nausea and fatigue. Ultimately, when kidney function becomes markedly impaired, death occurs—unless dramatic steps are taken. Such steps may include dialysis or kidney transplant. Without dialysis machines many people would die sooner from the consequences of their high blood pressure. However, even with dialysis, many experience a short extension of life accompanied by a significant decrease in their quality of life. For this reason, some people have even chosen to die rather than to begin or continue with dialysis.
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